Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein α subunits
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منابع مشابه
Antisense oligodeoxynucleotides directed against a novel angiotensinogen mRNA-stabilizing protein reduce blood pressure in spontaneously hypertensive rats.
We have previously reported that hypertension in the young spontaneously hypertensive rat (SHR) is associated with an elevation in tissue angiotensinogen and a novel polysomal protein known to stabilize angiotensinogen mRNA. In our current study we determined the role of the mRNA-stabilizing protein in the regulation of tissue angiotensinogen expression and mean arterial pressure (MAP) in the S...
متن کاملSelection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.
The aim of the present study was to identify functional antisense oligodeoxynucleotides (ODNs) against the rat glutathione S-transferase Mu (GSTM) isoforms, GSTM1 and GSTM2. These antisense ODNs would enable the study of the physiological consequences of GSTM deficiency. Because it has been suggested that the effectiveness of antisense ODNs is dependent on the secondary mRNA structures of their...
متن کاملGAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
terized G protein GAP is phospholipase C-b, which is Summary both a GAP for Gqa and the effector that is activated by that G protein (Berstein et al., 1992; Biddlecome et al., A novel class of regulators of G protein signaling (RGS) 1996). The GTPase activity of the a subunit of transducin proteins has been identified recently. Genetic eviis also stimulated by its effector, the g subunit of a r...
متن کاملMorphine-induced place preference affects mRNA expression of G protein α subunits in rat brain.
BACKGROUND The conditioned place preference (CPP) test is an animal model serving to assess addictive potential of drugs in which environmental cues become associated with the subjective effects of drugs of abuse. Morphine, a known addictive drug, is an agonist of opioid receptors that couple to the G(i/o) family of guanine nucleotide-binding proteins (GP). We have recently found that chronic t...
متن کاملAntisense pro-drugs: 5'-ester oligodeoxynucleotides.
Oligonucleotides bearing a terminal lipophilic group attached through a biodegradable ester bond should be useful as antisense pro-drugs with improved cellular uptake. The synthesis of 5'-ester oligonucleotides is, however, problematic due to lability of the ester bond during aqueous ammonia treatment that is commonly used for the deprotection of synthetic oligonucleotides. The synthesis of 5'-...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2001
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0704081